I love Medicine. 
Things I Never Needed fits. They can easily slow it down then kick it right back up. A slow song or two every album is wise.
The others (Tiny Light, Oasis, and Hot Summer Night) are growing.
I would like Sugar, Your Time is Gonna Come, and Paint it Black to make it back into their setlists.

As for make or break, the record company might see it that way. But us die-hards will always be here, and the fan base is growing either way.