The Wnt family of secreted glycoproteins is usually a group of signaling molecules broadly involved in developmental processes and oncogenesis.4, five Nineteen human Wnt proteins have thus far been identified. Transduction of Wnt signals is triggered by the binding of Wnt ligands to two distinct households of cellsurface receptors: the frizzled (Fz) receptor family and also the LDLreceptorrelated protein (LRP) family.six Intracellularly, Wnt signaling activates disheveled (Dvl) proteins, which inhibit glycogen synthase kinase3 (GSK3) phosphorylation of catenin, major to its cytosolic stabilization. Stabilized catenin then enters the cell nucleus and associates with LEF/TCF transcription factors. cateninTcf/Lef induces transcription of vital downstream target genes, lots of of which have already been implicated in cancer.