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The novel of Hamlet and Don Quixote are very different in theme but they are related in what they represented at the time. You can make the comparison that both were motivated by some sort of dementia as don Quixote makes a world of illusion while hamlet lives a life of revenge, in which he speaks to his dead father. In contrast, they both represent characteristics of human beings, they are opposite in nature because some of us are motivated in other ways than others. Some of us may be motivated by a feeling as revenge or love and other by inspiration. In any matter they are an exaggeration of our feelings, if you are motivated by revenge you will fall while if you are inspired by false pretences, you may not find the truth.
These two novels represented a change at the time as they moved away from the typical and focused into human imperfection. Don Quixote, for example, is an old man pretending to be a knight, who displays his human defect in contrast to the typical stories of a real knight who wins every battle and makes no mistake. And then, we have hamlet the prince in search of revenge which we expect to be romantic and win his battles, but he is actually human and by revenge he falls further into a tragedy.  These two novels are far from taking part in Arthur’s round table of nights and kings but they are the two first novels of the renaissance written to show the human deficiency that romantic novels did not.