I failed to answer your question:  no, I don't think Aronofsky is aiming at anything misanthropic.  And I do see subtlety in Requiem, although it might not be subtle to others.  I loved how he used the camera angels to show with pure image the narcissistic nature of the two kids' love affair.  In one of the most important philosophic/theological works in modern times, God Without Being, Jean-Luc Marion argues that all relationships are either idolotrous or iconic, the former a form of self love in disguise, the latter the other as a way to the transcendent, to escape self-absorbtion by moving out of oneself to higher ground (Beatrice in Dante).  The book is thick in its reasoningg, and I'd prefer a hiaku, a summing up, and Aronofsky does this with an image.  Also, the poem by Frost (I can't remember the title--I don't usually read poetry) where the man walking through the woods in a state of melancholy, and a piece of snow falls off a branch down his neck, and it shocks him back to centeredness, out of his self-absorbtion, and this is reminiscent of what they used to do in mental hospitals, a person in deep melancholy, throwing him in a tub filled with ice water.  And this is the appraoch of Aronofsky.  It can be maddening, but slow death is all around us.  Pi convinced me that Aronofsky's concern is that we reach each other, to not accept the death sentence.