I don't think you need to Americanise UK English for the US. Most people don't mind and some actually like UK English (which is why imports are popular). A much bigger issue is how on earth you make yourself known amidst all that noise.... Everyone seems to be publishing to Kindle right now.

I can’t imagine paying for translations of my own work and putting them into 'print'. Leaving the costs aside, how would you know if it was a decent translation?