This report is to present the results of re-radiation and Casodex 150mg/day in patients with locally advanced, previously radiated prostate cancer. These 45 patients with locally advanced progressing prostate cancer were treated with further radiation to total prescription dose of 3120 cGy and Casodex 50mg T.I.D. These patients have shown alternative therapeutic treatment resulting in significant improvement in quality of life. Further clinical studies are warranted.